An antifungal agent from the group of imidazole derivatives for external and local applications reduces the synthesis of ergosterol, which is a part of the cell membrane of the microbial wall and leads to a change in its structure and properties. In fungicidal concentrations, it interacts with mitochondrial and peroxidase enzymes, leading to an increase in the concentration of hydrogen peroxide to toxic levels, which also contributes to the destruction of fungal cells. The pills are active against pathogenic dermatophytes, pathogens of multi-colored lichen, erythrasma, gram-positive and gram-negative bacteria.
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The medicine is aimed at treating hypertension. It is also prescribed for patients with coronary heart disease and chronic heart failure.
The medicine is a selective adrenoreceptor blocking agent. It has no pronounced characteristics that would block the membranes. It is almost unlike beta receptors with smooth muscles and with receptors that do not participate in the regulation of metabolism. The tablets do not affect the respiratory resistance and metabolic effects. The selectiveness of the drug component extends beyond its dose range. The tablets have no negative inotropic effect.
The maximum result may be achieved in three to four hours after taking the pills. The components of the remedy are eliminated from the body after 10-12 hours. It falls into disuse from the body for a half and this leads to the fact that it is effective 24 hours after taking. The cure is not effective immediately and its maximum effect is achieved after two weeks of administration.
In case if the therapy is intensive, the patients who have ischemic heart disease and who do not have chronic heart failure may take pills to reduce the cardiac output and the myocardial need in oxygen. This is achieved by reducing the stroke volume. If the therapy lasts for a long time, the high peripheral resistance will be not so strong. There is a mechanism that reduces the activity of renin in plasma is the heart of beta blockers.
The medicine should not be taken by people who have an acute cardiac failure that requires inotropic therapy, for those who have cardiogenic shock, blockade of II and III degrees, weakness of the sinus node, symptomatic bradycardia, hypotension, for people who suffer from severe asthma, bronchial allergy or who have blood circulatory disorders. Taking tablets is also contraindicated for those who have metabolic acidosis, and hypersensitivity to other components of the pills.
The pills may cause the disorders of heart function such as bradycardia (in people who have a chronic cardiac failure). Sometimes there are worsening of heart failure in patients with chronic disease. Common deterioration of AV conduction and the appearance of the ischemic disease may occur. The medicine has an impact on the nervous system causing dizziness or a headache. Regarding the organs of vision, there are sometimes pour tear secretion (be sure to take into account if you wear contact lenses) and conjunctivitis. The cure has an adverse reaction to the hearing organs leading to its aggravation. From the sideline of the respiratory system, there may be bronchial asthma or allergic rhinitis. There are sometimes disorders in the digestive tract such as:
The medicine may have an undesirable effect on skin and tissue. Hypersensitivity reactions that include redness of the itchy skin and rash occur rarely. If one is treated with beta blockers, you can see the deterioration of people with psoriasis that changes into psoriatic rashes. On the part of the muscular system, there is a weakness in the muscles or seizures.
Sometimes there are mental disorders, depression, sleep disturbance. There are also nightmares and hallucinations. With regard to general disorders, patients may suffer from asthenia. It concerns only those patients who have coronary heart disease. The adverse reaction appears mainly only at the beginning of therapy and may continue for the first two weeks.