A combined medication used for edema syndrome of various origins and arterial hypertension. The effect is due to the components in its composition; it has diuretic and hypotensive effect. Hydrochlorothiazide is a diuretic of average power action, increases the excretion of Na+, Cl-, K+, Mg2+, bicarbonate; keeps Ca2+, uric acid in the body. Amiloride decreases the excretion of K+ and Mg2+. The combination of the drug components reduces the risk of hypokalemia and hypomagnesemia development.
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Moduretic Product Description
Moduretic is a combination antihypertensive agent that not only reduces the blood pressure, but also minimizes risks of loss of potassium. This combination of therapeutic effects allows to use Moduretic, when other drugs for hypertension treatment are contraindicated or not effective.
Moduretic is indicated in such diseases as:
- Hypertension with a low potassium level or without it
- Peripheral oedema of cardiac origin
- Cirrhosis of the liver complicated by ascites
Moduretic dosage depends on the therapeutic indications. Typically, the patients are advised to take one whole or a half of Moduretic pill once a day. The maximum dosage is two tablets of Moduretic per day.
If you’ve missed a dose of Moduretic, take it as soon as you remember. If it is nearly time for the next dose of Moduretic, do not take it at all, and go back to you regular dosing schedule on the next day.
The application of therapeutic doses of Moduretic not only normalizes the blood pressure, but also helps to control the balance of electrolytes. During intake of Moduretic tablets, a waist circumference and bodyweight are reduced in the patients with cirrhosis of the liver.
Moduretic tablets should be stored in a dry place at room temperature (not above 30°C).
Moduretic Safety Information
The application of Moduretic allows to maintain an acceptable level of potassium in the blood plasma, however, the anti-hypertensive agent may cause hyperkalemia in some patients. The patients with severe hepatic abnormalities, the patients older than 55 years and the patients with metabolic disorders are considered to be at higher risk of hyperkalemia comparing to other groups of patients.
Information about antihypertensive activity of Moduretic, stipulated in this review, is intended solely for general information. This information in no way is intended to be used as a substitute for the independent medical judgment of a cardiologist, therapist or any other health professional. The online pharmacy shall disclaim any implied warranties for any damage, which may be caused by using this information about Moduretic.
Moduretic Side Effects
In most patients, adverse reactions are related to the diuretic effect of Moduretic, and are characterized by frequent urination. In rare cases, anti-hypertensive agent Moduretic may cause: insomnia, somnolence, depression, nervousness, headache, weakness, fainting, irregular heartbeat, nausea, vomiting, rash, itch, dyspnea, muscle cramps, joint pain, bad taste, visual disturbance or angina.