Exforge the combined antihypertensive which includes amlodipine and valastran. Valsartan - a specific blocker of AT1 receptors of angiotensin II. Amlodipin - calcium channel blocking agents of III generation, inhibits transmembrane receipt of Ca2+ in cardiomyocytes and smooth muscle cells of vessels, by weakening them.
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Exforge product description
Exforge is a complex double-acting drug that contains 2 mutually interdependent basic substances. The first is a derivative of the dihydropyridine called amlodipine, which acts by plugging slow calcium channels. The second, named valsartan, causes competitive suppression of AT1 angiotensin II receptors. Both basic components correlate with each other. It is proved that in a complex they demonstrate more efficacy than it is shown in cases of monotherapy with a help of amlodipine or valsartan. Exforge is designed for the combined medical care of patients who suffer from a high blood pressure.
Exforge safety information
The pills of this pharmaceutical are swallowed regardless of the food intake, 1 time per day. The dosage depends upon the indicator of arterial pressure in the patient and the individual tolerability of the remedy. Exforge is not received to treat children, within pregnancy and breastfeeding. Exforge must not be assigned to treat patients with individual intolerance to valsartan, amlodipine, or any of the auxiliary components. Exforge is not prescribed for patients who have recently undergone renal transplantation or suffered from stenosis of the renal arteries. Patients experiencing the impaired hepatic function, hypertrophic obstructive cardiomyopathy, obstruction of the biliary tract, renal disorders, stenosis of an aorta, mitral stenosis, hyponatremia require additional medical care when using this combined drug.
There were no reports of an overdosage by Exforge. Theoretically, there appears the likelihood of development of hypotension, dizziness, reflex tachycardia, shock. Swallowing a large number of pills by mistake, you must induce vomiting, clean the stomach, take sorbents. The proper patient's position in case of the overdose and development of hypotension to lie with raised legs. The healthcare specialist may prescribe a vasoconstrictor preparation, ask to take calcium gluconate as the hemodialysis is ineffective.
Exforge side effects
The reception of Exforge pills can be accompanied by nasopharyngitis, constipation, flu-like conditions, cough, exanthema, headache, paresthesia, dizziness, erythema, epigastric pain, sore throat, hyperhidrosis, muscle spasms, visual impairment, drowsiness, nausea, tachycardia, itching, facial pastness hyperglycemia, hyperplasia of the mucous gums, arthralgia, erythema multiforme, dry mouth, tinnitus, gastritis, laryngeal spasm, orthostatic dizziness, anxiety, polyuria, angioedema edema, pancreatitis, diarrhea, hot flashes, swelling of the joints, vasculitis, erectile dysfunction, hepatitis, a feeling of heaviness, gynecomastia, back pain, rhinitis, urticaria, thrombocytopenia, alopecia, peripheral edema, dyspnea, leukopenia, asthenic conditions, pollakuria, increased angina, pulmonary edema, mood lability, rhythm disturbances, insomnia, sinusitis, increased creatinine levels, neutropenia, peripheral neuritis pathology, anaphylaxis.